A Compendium of Clinical Research and Practice


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WOUNDS is the most widely read, peer-reviewed journal focusing on wound care and research. WOUNDS articles target dermatologists, surgeons, internal medicine and family practitioners, podiatrists, gerontologists, infectious disease physicians, nurse practitioners, physician assistants, and researchers. WOUNDS provides in depth research on tissue repair and regeneration, biology and biochemistry of wound healing, and clinical management of various wound etiologies. Whether dealing with a traumatic wound or a diabetic foot ulcer, wound care professionals turn to WOUNDS for the latest in research and practice.
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Bioengineered skin equivalent
Negative pressure wound therapy
Acellular dermal matrix
Diabetic neuropathy
Silver dressings
Enzymatic debridement

Autolytic debridement
Wound necrosis
Surgical debridement
Mechanical debridement
Wound fibroblasts
Delayed wound healing
Impaired wound healing
Compression stockings
Diabetic foot wounds
Pressure dressing

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Feature Article
Topical Captopril as a Novel Agent Against Hypertrophic Scar Formation in New Zealand White Rabbit Skin
Gholamreza Safaee Ardekani, MD;1,2 Saeed Ebrahimi, MD;2 Mitra Amini, MD, MPH;2 Fatemeh Sari Aslani, MD;3 Farhad Handjani, MD;4 Gholamhossein Ranjbar Omrani, MD;1 Leila Safaee Ardekani, BS;1 Seyed Hamidreza Hosseini Alhashemi, MD;1 Behrooz Kasraee, MD1,5


C ollagen constitutes the majority of extracellular matrix in tissues such as bone, cartilage, and especially the skin. Over production and/or decreased degradation of collagen fibers could lead to an abnormal wound healing response resulting in hypertrophic scarring or keloid formation. Recently, angiotensin II has been shown to be present in several cutaneous cells and that it stimulates fibroblast proliferation, collagen synthesis, and suppresses matrix metalloproteinase activity. The following study examines the effect of topical captopril, an inhibitor of angiotensin II production, against hypertrophic scar formation in New Zealand white rabbits.Two dermal wounds were made over the ventral surface of the ears of each rabbit (n = 6). In each animal, separate wounds were treated once per day with either topical 5% captopril or the vehicle alone (70% ethanol and 30% propylene glycol) for 7 consecutive days.

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Evidence - Based Wound Care Standards in the Clinical Setting:

APPLYING THE KNOWLEDGE TO REAL - WORLD PRACTICE

Supplement to Wounds
September 2007


COMPLIMENTARY Web Archive

Debridement: Clinical and Economic Realities
CME, CPME & CE accredited web archive

This activity is supported by an educational grant from Healthpoint Ltd.
Debridement
COMPLIMENTARY LIVE Webcast

Infection Prevention for Minimally Invasive Interventions:

On Demand: Web Cast

Understanding Collagen Dressings and their Benefit in Wound Care

Complimentary Archived Webcast

This educational program is designed to provide clarity as to the benefit in wound care of the many different collagen based dressings on the market. It will begin with a timeline and general overview of many collagen dressings in existence followed by the clinical benefit they provide to healing wounds from a scientific perspective. The session will end with a practicing wound care clinician discussing the benefit of these dressings for the everyday practice of healing chronic wounds.
The Pharmacological Management of Diabetic Peripheral Neuropathy:
A Review of Remittive vs. Palliative Therapy

Complimentary Accredited Webcast

Wednesday, October 24th 2007 1:00PM EST

This activity has been developed for Vascular Surgeons, Endocrinologists, Podiatrists, Nurses, Primary Care Physicians, Wound Care Specialists, and Diabetic Educators. .
New Treatment Strategies for the Endovascular Approach to Critical Limb Ischemia:
ADVANCEMENTS IN LIMB SALVAGE MEDICINE

Complimentary Accredited On-Demand Webcast

This activity has been developed for Interventional Cardiologists, Vascular Surgeons, Interventional Radiologists, Podiatric Physicians, Endovascular Allied Professionals, Endocrinologists, Wound Care Specialists, Directors of the Wound Care Clinic, and Primary Care Physicians, Pharmacists, Nurses and Technologists.
 
Hidden Healing: Restoring the Wound Micro Environment

Complimentary Satellite Web Archive

This activity is designed for Physicians, Nurses, Podiatrists who treat patients with wounds.
Combining Bilayered Living Cell Therapy with Minimally Invasive Vein Surgery: Current Treatment Strategies for Venous Ulcers

Complimentary Web Archive

This educational activity has been developed for physicians and podiatrists.
Feature Article
Chronic Wound Infection: Bacterial Colonization in the Dermal Pericolostomic Region
Valdemir Salles, MD;1 Sarhan Saad, MD, PhD;2 Delcio Matos, MD, PhD2


Little is known about the bacteriology of the pericolostomic skin region. Identifying these bacteria is important to reduce the morbidity resulting from this procedure both to control local infection and to reduce the risk of infection in other surgical sites. Objective. The scope of this study was to determine the prevalence and type of peristomal skin bacteria in colostomy patients. Methods. Thirty-four patients with a temporary colostomy were included in the study. Their mean age was 51.6 years. All patients had been colostomized for more than 7 weeks. Results. Tissue samples were obtained from the peristomal skin and were cultured. Escherichia coli was present in the peristomal skin of 81.2% of patients with malignant colorectal disease and in all cases of benign colorectal disease. The proportion of patients with Bacteroides fragilis (P = 0.021) and Klebsiella spp (P = 0.003) was higher.

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Supplements:

Special Publication:
The following is a collection of publications from Healthpoint intended to facilitate expeditious, cost-effective wound care management. There will be nine publications total.

Related Links:
Symposium on Advanced Wound Care (SAWC)
The Buck Stops Here
Association of Advanced Wound Care
Ostomy/Wound Management
Podiatry Today
Vascular Disease Management
Wound Healing Society

Article Submission:
All submissions for consideration should be submitted online using the Rapid Review Web-Based Review System at www.rapidreview.com. Authors should scroll down to HMP Communications and click on Author.

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