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Feature Article
Gholamreza Safaee Ardekani, MD;1,2 Saeed Ebrahimi, MD;2 Mitra Amini, MD, MPH;2 Fatemeh Sari Aslani, MD;3 Farhad Handjani, MD;4 Gholamhossein Ranjbar Omrani, MD;1 Leila Safaee Ardekani, BS;1 Seyed Hamidreza Hosseini Alhashemi, MD;1 Behrooz Kasraee, MD1,5
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ollagen constitutes the majority of extracellular matrix in tissues such as bone, cartilage, and especially the skin. Over production and/or decreased degradation of collagen fibers could lead to an abnormal wound healing response resulting in hypertrophic scarring or keloid formation. Recently, angiotensin II has been shown to be present in several cutaneous cells and that it stimulates fibroblast proliferation, collagen synthesis, and suppresses matrix metalloproteinase activity. The following study examines the effect of topical captopril, an inhibitor of angiotensin II production, against hypertrophic scar formation in New Zealand white rabbits.Two dermal wounds were made over the ventral surface of the ears of each rabbit (n = 6). In each animal, separate wounds were treated once per day with either topical 5% captopril or the vehicle alone (70% ethanol and 30% propylene glycol) for 7 consecutive days.
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 Understanding Collagen Dressings and their Benefit in Wound Care
Complimentary Archived Webcast
This educational program is designed to provide clarity as to the benefit in wound care of the many different collagen based dressings on the market. It will begin with a timeline and general overview of many collagen dressings in existence followed by the clinical benefit they provide to healing wounds from a scientific perspective. The session will end with a practicing wound care clinician discussing the benefit of these dressings for the everyday practice of healing chronic wounds. |
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 The Pharmacological Management of Diabetic Peripheral Neuropathy:
A Review of Remittive vs. Palliative Therapy
Complimentary Accredited Webcast
Wednesday, October 24th 2007 1:00PM EST
This activity has been developed for
Vascular Surgeons, Endocrinologists, Podiatrists, Nurses, Primary Care Physicians, Wound Care Specialists, and Diabetic Educators.
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 New Treatment Strategies for the Endovascular Approach to Critical Limb Ischemia:
ADVANCEMENTS IN LIMB SALVAGE MEDICINE
Complimentary Accredited On-Demand Webcast
This activity has been developed for Interventional Cardiologists, Vascular Surgeons, Interventional Radiologists, Podiatric Physicians, Endovascular Allied Professionals, Endocrinologists, Wound Care Specialists, Directors of the Wound Care Clinic, and Primary Care Physicians, Pharmacists, Nurses and Technologists. |
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Feature Article
Valdemir Salles, MD;1 Sarhan Saad, MD, PhD;2 Delcio Matos, MD, PhD2
Little is known about the bacteriology of the pericolostomic skin region. Identifying these bacteria is important to reduce the morbidity resulting from this procedure both to control local infection and to reduce the risk of infection in other surgical sites. Objective. The scope of this study was to determine the prevalence and type of peristomal skin bacteria in colostomy patients. Methods. Thirty-four patients with a temporary colostomy were included in the study. Their mean age was 51.6 years. All patients had been colostomized for more than 7 weeks. Results. Tissue samples were obtained from the peristomal skin and were cultured. Escherichia coli was present in the peristomal skin of 81.2% of patients with malignant colorectal disease and in all cases of benign colorectal disease. The proportion of patients with Bacteroides fragilis (P = 0.021) and Klebsiella spp (P = 0.003) was higher.
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