Antimicrobial Activity of Silver-Containing Dressings is Influenced by Dressing Conformability with a Wound Surface
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White et al.5 have pointed out the role of colonized and infected wounds in acting as reservoirs for resistant strains of bacteria and the risk of cross-infection within healthcare environments. To be effective across a wide range of patients, the antimicrobial activity of silver-containing barrier dressings needs to be maintained across wounds of all shapes and sizes, from uneven, shallow leg ulcers to deep pressure ulcers.
The present study demonstrates the effective bactericidal activity of a SCH dressing against antibiotic-resistant strains of 2 common wound pathogens—P. aeruginosa and S. aureus (MRSA). The ability of antimicrobial dressings to effectively control pathogens, such as MRSA, across a variety of wound types is an important step in infection control.12
While both silver-containing dressings are known to be effective at killing wound pathogens including MRSA in vitro,11,13 the present study indicates that antimicrobial effectiveness in the clinical setting may be influenced by the physical properties of the dressings themselves.
These findings suggest that the SCH dressing is likely to provide more widespread antimicrobial protection at the wound-dressing interface than the NSC dressing studied here. This difference can be attributed to variations in dressing design and in the ability to conform well to wound surfaces. This study suggests that a variety of factors are involved in ensuring the most effective use of silver-containing dressings for the management and prevention of wound infection.
1. Bowler PG, Duerden BI, Armstrong DG. Wound microbiology and associated approaches to wound management. Clin Microbiol Rev. 2001;14(2):244–269.
2. Sibbald RG, Williamson D, Orsted HL, et al. Preparing the wound bed—debridement, bacterial balance, and moisture balance. Ostomy Wound Manage. 2000;46(11):14–35.
3. Bowler PG. Progression toward healing: wound infection and the role of an advanced silver-containing Hydrofiber dressing. Ostomy Wound Manage. 2003;49(Suppl 8A):2–5.
4. Wright JB, Lam K, Burrell RE. Wound management in an era of increasing bacterial antibiotic resistance: a role for topical silver treatment. Am J Infect Control. 1998;26(6):572–577.
5. White RJ, Cooper R, Kingsley A. Wound colonization and infection: the role of topical antimicrobials. Br J Nurs. 2001;10(9):563–578.
6. Ovington LG. The truth about silver. Ostomy Wound Manage. 2004;50(9A Suppl):1S–10S.
7. Campton-Johnston S, Wilson J. Infected wound management: advanced technologies, moisture-retentive dressings, and die-hard methods. Crit Care Nurs Q. 2001;24(2):64–77.
8. Percival SL, Bowler PG, Russell D. Bacterial resistance to silver in wound care. J Hosp Infect. 2005;60(1):1–7.
9. Parsons D, Bowler P, Myles V, Jones S. Silver antimicrobial dressings in wound management: a comparison of antibacterial, physical, and chemical characteristics. WOUNDS. 2005;17(8):222–232.
10. Tachi M, Hirabayashi S, Yonehara Y, Suzuki Y, Bowler P. Comparison of bacteria-retaining ability of absorbent wound dressings. Int Wound J. 2004;1(3):177–181.
11. Bowler PG, Jones SA, Walker M, Parsons D. Microbicidal properties of a silver-containing hydrofiber dressing against a variety of burn wound pathogens. J Burn Care Rehabil. 2004;25(2):192–196.
12. Jones SA, Bowler PG, Walker M, Parsons D. Controlling wound bioburden with a novel silver-containing Hydrofiber dressing. Wound Repair Regen. 2004;12(3):288–294.
13. Gallant-Behm CL, Yin HQ, Liu S, et al. Comparison of in vitro disc diffusion and time kill-kinetic assays for the evaluation of antimicrobial wound dressing efficacy. Wound Repair Regen. 2005;13(4):412–421.
14. AQUACEL Ag [package insert]. Skillman, NJ: ConvaTec; 2002.
15. Bowler PG, Jones SA, Davies BJ, Coyle E. Infection control properties of some wound dressings. J Wound Care. 1999;8(10):499–502.
16. Robinson BJ. The use of a hydrofibre dressing in wound management. J Wound Care. 2000;9(1):32–34.
17. Acticoat [package insert]. Hull, UK: Smith & Nephew; 2002.
18. Demling RH, DeSanti L. The role of silver in wound healing. Part 1: effects of silver on wound management. WOUNDS. 2001;13(1 Suppl A):5–14.
19. Yin HQ, Langford R, Burrell RE. Comparative evaluation of the antimicrobial activity of ACTICOAT antimicrobial barrier dressing. J Burn Care Rehabil. 1999;20(3):195–200.