Decreased Incidence of Hypertrophic Burn Scar Formation with the Use of Collagenase, an Enzymatic Debriding Agent
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Independent studies by Ghahary et al.4 and Arakawa et al.5 have indicated that there is a decreased expression of collagenase in hypertrophic scar fibroblasts.
The clinical study reported here suggests a decreased incidence of hypertrophic scar formation in the partial-thickness burn wound with the application of topical collagenase to the wound. The use of collagenase should be considered for management of the partial-thickness burn wound because of this decrease in hypertrophic scar formation. However, a prospective study is needed to confirm these findings as well as to define a mechanism for the effects of collagenase on scarring.
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