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Best in Class: Scottsdale Wound Management Guide

Comprehensive pocket handbook offers differential diagnosis and treatment options at your fingertips

Malvern, PA (June 8, 2009) – Proper wound care management has become one of the top concerns for many clinicians across various medical specialties. Treatment is specific to the wound type, the patient and the long-term care plan and requires ongoing assessment. Read More

2009 WOUNDS Article Index

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Review

Closure of Difficult Wounds by External Tissue Expansion

VOLUME: PUBLICATION DATE: Jun 01 2010
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Issue: 
6: June 2010

  Abstract: The open nonhealing wound is a persistent challenge to physicians. Infections, foreign bodies, osteomyelitis, and skin coverage of repaired structures remain problems. As the body ages, the elderly are prone to the development of pressure sores and foot ulcers, particularly patients with diabetes. Many elderly patients will have comorbid conditions making closure of these wounds difficult. The authors have more than 100 combined years of experience treating wounds. Throughout their long careers the authors have treated numerous wounds with various types of methods.

Off-label Use of Prescription Medication: A Literature Review

VOLUME: 22 PUBLICATION DATE: Apr 01 2010
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Issue: 
4 April 2010

Abstract: The following review will describe the available literature and outline the concept and practice of off-label prescribing. Phenytoin, misoprostol, and nifedipine will be critically reviewed with emphasis on their functional components, mechanisms of action, and patient considerations regarding wound healing. Recipes of off-label medications also will be offered.


     Wound management guidelines have been established to assist healthcare professionals in providing the most advantageous treatment to promote wound closure. Organized decisions that are o

Hyperbaric Oxygen Therapy as an Adjunctive Treatment for Diabetic Foot Wounds: A Comprehensive Review With Case Studies

VOLUME: 22 PUBLICATION DATE: Jan 01 2010
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Issue: 
1 January 2010

Abstract: Complications associated with diabetes are often expensive to treat, and commonly include foot ulceration. While most diabetic foot ulcers heal with standard treatment, when standard treatment measures fail, adjunctive therapies must be considered. We review the theory and evidence for the use of systemic Hyperbaric Oxygen Therapy (HBOT) as an adjunctive treatment for chronic lower extremity diabetic ulceration. Two clinical cases of patients treated with HBOT for refractory diabetic foot ulceration at Georgetown University Hospital are presented. A growing body of evidence suggests

Using Evidence-based Principles To Achieve Sustained Behavior Change

VOLUME: 21 PUBLICATION DATE: Dec 01 2009
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Issue: 
12 December 2009

Abstract: This narrative review outlines the potential benefits of supporting clients to successfully change existing patterns of behavior in the context of wound care. In acknowledging the complexities involved in changing deeply ingrained patterns of behavior, the case for developing interventions based on evidence is presented. The evidence-based psychological targets, which are recommended for inclusion in behavior change interventions, are outlined together with their theoretical derivatives. An example of an intervention developed using evidence-based techniques is presented. The

Autologous Cell Therapy: Current Treatments and Future Prospects

VOLUME: 21 PUBLICATION DATE: Sep 15 2009
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Issue: 
9 September 2009

Abstract: Autologous cell therapy (ACT) is a novel therapeutic intervention that uses an individual’s cells, which are cultured and expanded outside the body, and reintroduced into the donor. Advantages of such an approach include the minimization of risks from systemic immunological reactions, bio-incompatibility, and disease transmission associated with grafts or cells not cultivated from the individual. So far, this form of therapy has been used successfully to bioengineer skin substitutes, aid wound healing, counteract chronic inflammation, treat burns and pressure ulcers, and improve po

Microarray as a New Tool To Study Hypertrophic and Keloid Scarring

VOLUME: 21 PUBLICATION DATE: Feb 12 2009
Issue: 
2 February 2009

Abstract: Background. Normal wound healing results from a complex set of reactions between blood cells, skin cells, and biochemical mediators including pro- and anti-inflammatory molecules, growth factors, cytokines, hormones, and vitamins. As this cascade of reactions is ultimately regulated by the coordinated expression and silencing of numerous genes, the gene expression analysis of hypertrophic and keloid scarring (HS and KS, respectively) should provide important information and improve our understanding of HS and KS pathophysiology. Microarray is a new tool that can shed light on the com

A Review of Collagen and Collagen-based Wound Dressings

VOLUME: 20 PUBLICATION DATE: Dec 01 2008
Issue: 
12 December 2008

Abstract: Collagen is a key component of a healing wound. In this review, a general description of the wound healing process is provided focusing on collagen’s unique role. The mode of action (MoA) of collagen-based dressings is also addressed. Due to a number of potential stimuli (local tissue ischemia, bioburden, necrotic tissue, repeated trauma, etc.), wounds can stall in the inflammatory phase contributing to the chronicity of the wound. One key component of chronic wounds is an elevated level of matrix metalloproteinases (MMPs). At elevated levels, MMPs not only degrade nonviable

New Topical Agents for Treatment of Partial-thickness Burns in Children: A Review of Published Outcome Studies

VOLUME: 20 PUBLICATION DATE: Nov 01 2008
Issue: 
11 November 2008

Abstract: Evidence-based choices for treating burns in children are not well defined. Skin substitutes and contemporary dressings offer potential advantages over traditional treatment with topical antimicrobial agents in treating partial-thickness burns. Newer treatment modalities may reduce morbidity, financial burdens, and scarring by accelerating healing.
     Reports of pediatric burn management from 1997 to 2007 were reviewed to compare agent performance with outcome measures such as healing time, pain moderation, cosmetic results, and hospital costs. Transcyte™



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