Volume 21 - Issue 10 - October, 2009
Effect of Experimental Ehrlich Ascites Tumors on Healing of Abdominal Wall Wounds in Mice
- 10/14/2009
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Abstract: Many systemic factors may influence the healing process. The present study aimed to analyze histological modifications induced by the presence of Ehrlich ascites tumors on laparotomic surgical scars in BALB/c mice. A total of 52 mice were used. Half of the mice were injected with Ehrlich tumor cells, and 7 days later (day 7) all mice underwent laparotomy. On day 11, the scar was resected in 10 mice with the tumor and in the 10 control mice. The procedure was repeated on day 14 with the remaining animals. The scar tissue was histologically evaluated by means of semiquantitative analys
A Pilot Study of Ultrasonically-assisted Treatment of Residual Burn Wounds
- 10/14/2009
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Abstract: Objective. To evaluate the use of a noninvasive, low-frequency ultrasound device to treat residual burn wounds as an adjunct to regular wound dressing therapy. Methods. Nineteen patients with 38 residual wounds (served as self control) with an average post-burn duration of 94.6 days were recruited. Low-frequency ultrasound at 40 kHz was delivered in the ultrasonic group by a handheld probe, using normal saline as the irrigation medium. The control group had dressings changed with saline used as the coupling medium. Each wound was treated for 2 weeks (a total of 7 treatments; once eve
Oxidative Stress Markers Regulating the Healing of Foot Ulcers in Patients With Type 2 Diabetes
- 10/14/2009
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Abstract: Objective. This study was aimed at identifying factors that affect the healing of foot ulcers among patients with type 2 diabetes, focusing on the evaluation of oxidative stress—one marker of the inflammatory response. Methods. A cross sectional study comprised of 96 subjects who were divided into 6 groups (16 subjects in each group). The groups were classified as non-diabetic control (group I), diabetic subjects without foot ulcer (group II), diabetic subjects with foot ulcers were sub-divided as neuropathic ulcer-noninfected (group III), neuropathic ulcer-infected (group IV), neu
Autologous Platelet-rich Plasma Enhances Healing of Chronic Wounds
- 10/14/2009
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Abstract: Chronic wounds are a frequent problem in developing countries, are often difficult to heal because they lack the necessary growth factors to maintain the healing process, and are frequently complicated by superinfection. Conventional therapies such as dressings, surgical debridement, and even skin grafting cannot provide satisfactory healing since these treatments are not able to provide enough necessary growth factors to modulate the healing process. Platelet-rich plasma (PRP), as a concentrate of platelets, releases a high concentration of multiple growth factors that can modulate
Daptomycin for the Treatment of Osteomyelitis Associated With a Diabetic Foot Ulcer
- 10/14/2009
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Abstract: This report describes a case of Staphylococcus aureus osteomyelitis associated with a chronic foot ulcer that was successfully treated with surgical debridement and 6 weeks of daptomycin therapy. Daptomycin was chosen because of its excellent activity against the causative organism and the patient’s history of penicillin allergy. Its tolerability and ease of administration also facilitated long-term outpatient management. The present case provides further evidence that supports consideration of daptomycin as a treatment for S aureus osteomyelitis, especially in light of reports of
Fact or Fiction?
- 10/14/2009
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Dear Readers,
Wound care education involves reading many books, journals, and other sources of information. I have addressed this issue in a past editorial (November 2008), and the need to obtain information by way of the printed word has not changed. Are you sure what you’re reading is fact or is it fiction? That is a menacing thought since we depend on scientific writing to be factual. Unfortunately, many articles are sponsored by companies who have much to gain by the publication of favorable words for their products or services. The pressure for publishers to publi
Documentation: The Crystal Ball of Wound Care
- 10/14/2009
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Dear Readers:
The global epidemic of type 2 diabetes can be managed if we recognize and alleviate its causes as early as possible.1 A diabetic foot ulcer (DFU) need not be a sentence to amputation and early death with pre-emptive evaluation and effective care. Early detection of sensory loss, bone and soft tissue injury, impending infection,2 and consistent 24/7 off-loading3 are important steps toward healing and maintaining a healthy diabetic foot. The 80%–90% healing in 12 weeks reported for non-infected, non-ischemic Wagner Grade 1 and 2 foot ulcers t
Industry News October 2009
- 10/14/2009
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Advanced BioHealing Outlines Strategic Growth Plan to Set Professional Precedence
Advanced BioHealing Inc (Westport, Conn) announced a strategic growth plan designed to continue the transformation of this former start-up company into the leading international regenerative medicine company. The company which manufactures and markets Dermagraft®, a bioengineered skin substitute that repairs tissue damage caused by disease or injury and supports the body’s natural healing process in patients with diabetic foot ulcers. To spur future growth, executive management
Product News October 2009
- 10/14/2009
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Smith & Nephew Launches Antimicrobial Dressings
Smith & Nephew’s Advanced Wound Management division (Hull, United Kingdom), is launching two extensions to the Allevyn Ag™ range of dressings—Allevyn Ag™ Gentle Border and Allevyn Ag™ Gentle. These dressings will combine the antimicrobial protection of silver with the gentleness of silicone and soft gel adhesives that have been specifically designed to minimize patient pain and trauma to the wound at dressing removal. These two new Allevyn Ag variants are available in a range of sizes and offer patients a
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