Index: WOUNDS 2012;24(2):29–35

  Abstract: Many factors are known to play a role in flap necrosis, such as inadequate blood flow and disturbed venous drainage, which lead to decreased flap nutrition and necrosis. The aim of this study was to determine whether adrenomedullin (ADM) and glucagon-like Peptide-1 (GLP-1) administered at various doses directly to the superficial inferior epigastric artery (SIEA) had an effect on the normal healing process of flap tissue. Methods. Under 3% isoflurane anesthesia, the rats were put in the dorsal decubitus position before the surgery. A cutaneous flap 8 cm x 3 cm in size was marked on the abdominal wall, divided into four equal sections, and marked from 1 to 4 (proximal to distal). A laser Doppler flowmeter was used to measure the blood supply of each area in the flap tissue. On the seventh postoperative day, an image of the final condition of the flap was obtained with a 5-megapixel camera; the rats were sacrificed afterward. Results. Groups treated with ADM or GLP-1 showed a statistically significant increase in the blood flow of the four separate regions compared to the saline group. The percent necrosis area decreased in a statistically significant manner in the groups treated with ADM and GLP-I. Conclusion. The authors believe that both peptides play an important role in the normal flap recovery process.

Index: WOUNDS 2012;24(2):43–46

Presentation

  Malignant melanoma, although rare, is a skin cancer with the highest mortality. This report presents a 55-year-old man who had been followed-up for diabetes mellitus for 14 years, and was diagnosed with a malignant melanoma that had developed on the base of a diabetic foot ulcer. The major common characteristic of malignant melanomas misdiagnosed as foot ulcer in the literature was that these cases have a very aggressive course, and metastasize in a short time. Thus, early biopsy is required in painful, pigmented foot ulcers with atypical localization that do not respond to standard treatment in patients with diabetes.

The AAWC Celebrates the 25th Anniversary of the Symposium on Advanced Wound Care by Offering a 25% Limited-time Discount on 2012 Clinician Membership Dues!

  In recognition of the SAWC’s 25th Anniversary in Atlanta, April 19–22, the AAWC is offering clinician members a 25% discount on membership dues. Join or renew before April 30 to take advantage of the savings. Promotion ends on May 1.

  The new dues rate is $108.75 instead of $145.00. This limited-time clinician price is the lowest in more than 5 years! Then take that savings and join us for an extra 20% AAWC-member discount on the SAWC registration fee. To save even more, register for the SAWC Spring before the Early Bird discount ends on March 9! Remember, you must be an AAWC Member first to receive the discount.