Abstract: Negative pressure wound therapy (NPWT) has become an accepted method to assist in optimizing the management of wounds. It can decrease the frequency of dressing changes, which reduces pain and fear in pediatric patients. An 8-year-girl with lower extremity avulsion injuries underwent debridement and received NPWT for 17 days. The dressing foam was changed only twice during NPWT. Secondary skin grafting was performed 24 days later, and the wound was resurfaced 35 days after injury. Negative pressure wound therapy reduces the frequency of required dressing changes, even while the wound releases massive exudate, which reduces pain and brings comfort to injured children.