Volume 24 - Issue 7 - July 2012
Effect of Topical Insulin Application on Wound Neutrophil Function
- 7/1/2012
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Index: WOUNDS. 2012;24(7):178–184.
Abstract:This study observed the quantity and functions of wound neutrophils after topical insulin treatment and investigated the effect of insulin on the wound inflammatory response, as well as the mechanism of insulin-induced wound healing. Methods. Full-thickness excisional wounds were made on the dorsal symmetrical site of C57BL/6J mice. The wounds were treated with either 0.03U insulin/20 µL saline or 20 µL saline. The healing times and healing rates of the wounds were recorded. The wounds and adjacent tissues were collected during the first 3 consecutive days after the injury. Quantification of myeloid differentiation antigen Gr-1, myeloperoxidase (MPO), malondialdehyde (MDA), and macrophage inflammatory protein-2 (MIP-2) were measured by Western blotting, biochemical analysis, and real-time polymerase chain reaction (PCR), respectively.
Tissue Augmentation and Replacement of a Heel Fat Pad With a Decellularized Sterile Human Dermal Matrix
- 7/1/2012
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Index: WOUNDS. 2012;24(7):185–189.
Abstract: The use of xenografts and allografts has been primarily directed at chronic wounds and tendon repair. Currently, there are no known devices in this category that can successfully be used to augment tissue. Patients who have undergone trauma and subsequent surgery, particularly in weight-bearing areas, may experience pain with pressure or ambulation at the site. This report illustrates the use of an allograft for tissue augmentation in a young individual who was involved in a motor vehicle accident resulting in loss of the plantar fat pad. An allograft was successfully used for tissue replacement, thereby reducing pain and facilitating weight-bearing ambulation.
The Effect of Pentoxifylline on Chronic Venous Ulcers
- 7/1/2012
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Index: WOUNDS. 2012;24(7):190–194.
Abstract: Venous ulcers affect approximately 1% of the world’s population, increasing health care expenditures and decreasing quality of life. Several hypotheses may help explain their origin. Insufficient veins or valves or impaired muscle function may lead to abnormal calf muscle pump function that can elevate ambulatory venous pressure. The aim of this study was to evaluate the efficacy of pentoxifylline in treating chronic venous ulcers. Methods. From May 2009 to March 2010, 40 patients with chronic venous ulcers were randomly assigned to 2 groups: a standard treatment group that received compression therapy or an intervention group that received oral pentoxifylline (400 mg, 3 times daily) in addition to compression therapy. Time duration of wound healing, edema, pain, and ulcer size in the 2 groups were studied. For all tests, P <0.05 was considered significant.
Simvastatin Improves Incisional Wound Healing in a Rat Model: An Experimental Study
- 7/1/2012
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Index: WOUNDS. 2012;24(7):195–200.
Abstract: This study investigated the effect of simvastatin on the healing process of abdominal wall wounds in rats. Methods. The study was performed with adult female Wistar-Albino rats. Control group (n = 20) rats were fed standard laboratory diet until 12 hours before surgery. Study group (n = 20) rats received oral simvastatin therapy with an orogastric tube (10 mg/kg once a day) for 7 days until 12 hours before surgery. Each rat was anesthetized, and a 4 cm-long midline laparotomy was performed. Ten animals from each group were killed at postoperative days (PODs) 7 and 14. Breaking strength analysis was measured, and the abdominal incision wounds were examined histologically. Results. Hydroxyproline levels and tensile strength of abdominal fascia were significantly higher in the study group on PODs 7 and 14 compared to the control group. The granulation tissue fibroblast maturation scores on POD 7, and both collagen deposition scores and neovascularization scores on PODs 7 and 14, were found to be statistically significantly higher in the simvastatin treatment group compared to the control group, based on the results of the histologic tissue examinations. Conclusion. Simvastatin can be used as a supporting therapy in wound healing.
Editorial Message: “I have no idea what that is!”
- 7/1/2012
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Dear Readers,
Have you ever experienced the unnerving feeling of dealing with a patient who seeks your help for a specific problem and you have absolutely no idea what is wrong, much less what to do about it? Apparently, our wound center is the regional headquarters for many of these patients. Rarely a day goes by that either one, or several, new patients are seen with problems that other health care providers have been unable to identify. One of our new patients had been seen by 6 physicians of various specialties over a 4-month period, and not one was able to identify the problem, much less devise a treatment plan. The patient, thinking she had a very peculiar problem for which there was no treatment, was about to give up. Fortunately, after taking a good history and performing a thorough physical exam, I recognized the problem and outlined a treatment plan for her. If all goes as expected, she should be significantly better within a week.
AAWC News
- 7/1/2012
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AAWC News
If you are a member of the AAWC attending the Symposium on Advanced Wound Care (SAWC) Fall, September 12–14 in Baltimore, look at these advantages:
• Members choose from more than 40 clinical sessions and earn up to 16 credits at a discounted rate
• Members are provided additional financial incentives (see below)
Industry News and New Products
- 7/1/2012
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Convatec Introduces AQUACEL Foam Dressing
ConvaTec (Charlotte, NC) introduced AQUACEL® foam dressing, the first dressing to combine a soft absorbent foam pad with the healing benefits of the company’s proprietary AQUACEL® interface for use in the management of wounds. The launch was presented at the 44th Annual Conference of the Wound, Ostomy and Continence Nurses (WOCN) Society in Charlotte, NC.
AQUACEL® foam dressing is specially designed to meet wound management challenges. It has a waterproof barrier that allows for the evaporation of excess moisture and protection against viral and bacterial penetration. The soft absorbent foam pad enhances patient comfort and absorbs excess fluid.
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