Volume 13 - Issue 12 - December, 2001
Topical Doxepin Cream is Effective in Relieving Severe Pruritus Caused by Burn Injury: A Preliminary Study
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Introduction
Severe pruritus or itching is a common and disabling problem in patients after burn injury.1–5 The mechanism is not clearly defined, but increased histamine release from the healed wound appears to play a role. Current standard of care is the use of antihistamines. Wound erythema is also typically found.5,6 The increased mast cell population in the burn wound is likely the source.1–5 It is known that histamine release occurs from a healed wound with minimal wound manipulation and is further exacerbated by increased skin temperature.5–8
Noncontact Thermal Wound Therapy Counteracts the Effects of Chronic Wound Fluid on Cell Cycle-Regulatory Proteins
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Introduction
Wound fluid has been implicated to play a critical role in the wound healing process.3,4 Acute wound fluid has been shown to stimulate the growth of fibroblasts and endothelial cells,5–7 induce chemotaxis,8 and increase production of extracellular matrix.6,7 In contrast, wound fluid from chronic venous ulcers (CWF) has been shown to inhibit cellular proliferation,9–11 contributing to the impaired healing of chronic ulcers. CWF inhibits the proliferation of newborn dermal fibroblasts,9–11 inhibits DNA synthesis in human neona
Multimodal Therapy for Approaching Difficult-to-Heal Wounds: Becaplermin in Combination with Sequential Living Skin Equivalent A
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Introduction
The vast majority of leg ulcers occur in patients with venous insufficiency; however, most patients with venous insufficiency do not develop leg ulcers.1 This observation suggests that additional factors may be involved in the etiology of leg ulcers. Data on leg ulcers from 1,380 patients revealed that over 70 percent of their ulcers could be classified as postthrombotic ulcers involving primary or secondary hypercoagulable states.2,3
Other causes of leg ulcers, which may present with or without venous disease, include a diverse group of disorders includin
Cost and Dressing Evaluation of Hydrofiber and Alginate Dressings in the Management of Community-Based Patients with Chronic
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Introduction
Patients with lower leg ulceration present a complex management situation for the practicing health professional. A number of factors should be considered by health professionals, including accurate diagnosis of the ulcer etiology and the formulation of a comprehensive, affordable treatment plan.1,2 In patients with such wounds, venous disease is the most common pathology seen in clinical practice. In these patients, it is accepted that compression of the limb is an essential component of the patient’s care. The primary wound contact material, although not alwa
Kaposi’s Sarcoma
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Case Study
A 94-year-old Caucasian man presented with an ulcer on the medial side of his left foot. His past medical history was significant for an 18-year history of Kaposi’s sarcoma on his hands and feet. Seven months prior to presentation, the patient developed an ulcer on the plantar surface of his left foot with cellulitis. The infection cleared with oral antibiotics and the ulcer healed approximately two months prior to his presentation, but recurred approximately four weeks prior to the visit. The ulcer was painful. He denied anesthesia, paresthesia, claudication, or previo
Commentary: The WOUNDS Year in Review
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In 2001, we have tried to maintain past improvements in WOUNDS while making some significant new changes to the Journal. It was the first full year in which our Section Editors had responsibility for individual journal issues. We also published six supplements ranging from topics on new product technology to educational offerings on wound care guidelines. In addition, we have added seven new members to the WOUNDS Editorial Advisory Board, thus strengthening the already impressive group. Our readership has grown to over 11,000 physicians and PhD researchers who specialize in the biology of wou
DD-Test
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Commentary: Biology and Treatment of Diabetic Foot Ulcers
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Diabetic foot ulceration (DFU) remains a serious healthcare problem. DFUs can seriously affect a patient’s quality of life with potential grave consequences, including prolonged hospitalization and lower-limb amputation. Furthermore, DFUs can have considerable socioeconomic impact because of the heavy economic burden they place on the health-providing system.
The encouraging news is that during the last two decades, our understanding of the physiology and pathophysiology of wound healing has increased dramatically, and, as a result, advanced treatments based on this knowledge are starti
June 2004 Industry News
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Collagenase Santyl® Found Effective in Reducing Hypertrophic Scarring and Length of Hospital Stay
Data supporting the use of a collagenase enzymatic debriding agent to reduce the rate of hypertrophic scarring in burn patients was recently presented at the 17th Annual Symposium on Advanced Wound Care by Arnold Luterman, MD, FRSC, medical director of the Regional Burn and Wound Center, University of South Alabama, Mobile. In the 1990s, Harry S. Soroff, MD, and J.F. Hansbrough, MD, found that using collagenase in partial-thickness burn patients showed a reduction in the time to a clean wound
Staphylococcus aureus is Associated with High Microbial Load in Chronic Wounds
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