Volume 20 - Issue 1 - January, 2008
Increased Quality in Negative Pressure Therapy Research
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Dear Readers:
Various regimens of subatmospheric pressure, also known as vacuum, negative pressure wound therapy (NPWT), or topical negative pressure (TNP), have been used to manage complex wounds. Limited evidence supports NPWT efficacy on chronic or acute wound healing,1,2 where it was mainly compared to less than optimal3 saline gauze control dressings. One best evidence review found NPWT to be an acceptable adjunct therapy in managing infected sternal wounds following cardiac surgery.4 Reviewers generally agree th
Relevance of Animal Models for Wound Healing
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Animal models and in-vitro assays have become indispensable tools for researchers in nearly every scientific discipline. In product development there is a need for translational research to obtain data that can lead to sound clinical trials and ultimately, improved wound care. This process is usually performed in a stepwise fashion starting with in-vitro testing, preclinical, and then clinical evaluations (Figure 1). 
January 2008
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Healthpoint Introduces New Medical Affairs Department
Healthpoint (Fort Worth, Tex) recently incorporated a new Medical Affairs department. The new branch’s mission is to develop and support scientific, clinical, and educational programs to help improve clinical outcomes. Working initiatives to achieve this goal include establishing collaborative partnerships with key opinion leaders, academic institutions, professional organizations, and advocacy groups, providing peer-level medical leadership and support for investigator-initiated research, and exploring clin
January 2008
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Coflex® AFD Foam Pad Dressing Provides All-In-One Wound Management
Andover Healthcare Inc (Andover, Mass) introduces CoFlex® AFD, an all-in-one foam pad dressing and cohesive bandage. The absorbent foam pad is attached to a CoFlex® LF2 compression bandage for easy application, which allows it to stick to itself without clips or fasteners while providing controlled compression.
Coflex’s applications range from treating venous leg ulcers and pressure ulcers to treating traumatic wounds, nonhealing su
Animal Models of Wound Healing
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For more than 20 years I have had the opportunity to work closely with many companies in the development of their products using animal models. Together with wound healing model pioneers William H. Eaglstein, MD and Prof. Patricia M. Mertz, we have evaluated numerous dressings, devices, and topical agents on healing1–11 and studied their effects on bacteria.12–18 Our objectives have been to develop both in-vitro and in-vivo models that can be used as a springboard to assess potential therapeutics prior to their clinical application.
Salt and Preserving Wound care
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Dear Readers,
Salt, an essential chemical for life and well-being, is ironically the combination of two of the most deadly chemicals known to man—sodium, an unstable metal that will burst into flame if exposed to air or water, and chlorine, one of the deadliest known gases. Yet this combination of chemicals produces sodium chloride, common table salt, which has been one of the most sought-after products in human history and is the only rock humans consume. Salt has more than 14,000 uses to make our modern lives better.1
Salt’s ability to
Animal Models of Wound Healing
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For more than 20 years I have had the opportunity to work closely with many companies in the development of their products using animal models. Together with wound healing model pioneers William H. Eaglstein, MD and Prof. Patricia M. Mertz, we have evaluated numerous dressings, devices, and topical agents on healing1–11 and studied their effects on bacteria.12–18 Our objectives have been to develop both in-vitro and in-vivo models that can be used as a springboard to assess potential therapeutics prior to their clinical application. Ho
Animal Models of Tissue Ischemia to Evaluate the Importance of Oxygen in the Wound Healing Environment
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Disclosure: This research was supported in part by a Dennis W. Jahnigen Career Development Scholars Award given to Dr. Gould.
The Importance of Oxygen
Effective and dependable influx and efflux of blood, fluid, and nutrient supply is essential for wound healing. The delicate balance between adequate oxygenation and hypoxia is an important aspect of this process. Two main factors lead to hypoxia after acute injury. First, disruption of the vascular supply to the tissue decreases the amount of oxygen that can be delivered t
Wound Healing Kinetics of the Genetically Diabetic Mouse
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With diabetes mellitus and obesity on the rise,1,2 and the increased prevalence of complex wounds and impaired healing,1,2 there is a crucial need to develop reliable wound repair models to identify effective therapeutic approaches.3,4
To be clinically relevant, an experimental model should appropriately reproduce the clinical situation physiologically and pathogenically.4 Experimental models can be either in vitro or in vivo.
In-vitro models are necessary in wound healing because of the orchestral f
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