Volume 14 - Issue 6 - June, 2002

Type II Cryoglobulinemia

Department Editor: Tania Phillips, MD, FRCPC

Overall Learning Objective: The physician or podiatrist participant will develop a rational approach to the evaluation and treatment of a variety of uncommon wounds and will have an increased awareness of the differential diagnosis of cutaneous wounds and the systemic diseases associated with these wounds.

Submissions: To submit a case for consideration in Diagnostic Dilemmas, e-mail or write to: Executive Editor, WOUNDS, 83 General Warren Blvd., Suite 100, Malvern, PA 19355, eklumpp@hmpcommunications.com

Completion



Hypertensive Ulcer

Department Editor
Tania Phillips, MD, FRCPC

Overall Learning Objective: The physician or podiatrist participant will develop a rational approach to the evaluation and treatment of a variety of uncommon wounds and will have an increased awareness of the differential diagnosis of cutaneous wounds and the systemic diseases associated with these wounds.

Submissions: To submit a case for consideration in Diagnostic Dilemmas, e-mail or write to: Executive Editor, WOUNDS, 83 General Warren Blvd., Suite 100, Malvern, PA 19355, eklumpp@hmpcommunications.com

Completion



Bullous Pemphigoid

Department Editor: Tania Phillips, MD, FRCPC

Overall Learning Objective: The physician or podiatrist participant will develop a rational approach to the evaluation and treatment of a variety of uncommon wounds and will have an increased awareness of the differential diagnosis of cutaneous wounds and the systemic diseases associated with these wounds.

Submissions: To submit a case for consideration in Diagnostic Dilemmas, e-mail or write to: Executive Editor, WOUNDS, 83 General Warren Blvd., Suite 100, Malvern, PA 19355, eklumpp@hmpcommunications.com

Completion



Venous Stasis Ulcer Complicated by Calcinosis Cutis

Department Editor: Tania Phillips, MD, FRCPC

Overall Learning Objective: The physician or podiatrist participant will develop a rational approach to the evaluation and treatment of a variety of uncommon wounds and will have an increased awareness of the differential diagnosis of cutaneous wounds and the systemic diseases associated with these wounds.

Submissions: To submit a case for consideration in Diagnostic Dilemmas, e-mail or write to: Executive Editor, WOUNDS, 83 General Warren Blvd., Suite 100, Malvern, PA 19355, eklumpp@hmpcommunications.com

Completion



Calciphylaxis

Department Editor: Tania Phillips, MD, FRCPC

Overall Learning Objective: The physician or podiatrist participant will develop a rational approach to the evaluation and treatment of a variety of uncommon wounds and will have an increased awareness of the differential diagnosis of cutaneous wounds and the systemic diseases associated with these wounds.

Submissions: To submit a case for consideration in Diagnostic Dilemmas, e-mail or write to: Executive Editor, WOUNDS, 83 General Warren Blvd., Suite 100, Malvern, PA 19355, eklumpp@hmpcommunications.com

Completion



COMMENTARY: Animal Models and Their Contribution to the FDA Approval Process for Topical Agents and Devices

I am pleased to address the readership of Wounds on this occasion of the second issue dedicated to animal models and their roles in wound repair and infection. I would like to take the Reader through a recent set of published experiments that examined a new experimental bandage using both the preclinical and clinical wound healing and infection models of our laboratory.

This device was approved by the Food and Drug Administration (FDA) for the over-the-counter consumer and was launched in January of this year. The name of the device is Band-Aid® Liquid Bandage, LAB. It is being marketed b



The Effect of an Antimicrobial Gauze Dressing Impregnated with 0.2-Percent Polyhexamethylene Biguanide as a Barrier to Prevent P

Introduction

Gauze-type dressings are designed to absorb fluid, protect the wound from the outside environment, and protect the outside environment from wound fluids. Many types of wound dressings have become commercially available over the past several years. Some of these dressings are known to provide physical protection for wounds;[1] however, few have been designed specifically to protect against invasion of external microorganisms with the potential to reduce the possibility of infection. The purpose of this study was to examine the protective barrier activity of a gauze dressing cont



Use of Mouse Footpad Model to Test Effectiveness of Wound Dressings

Introduction

Acemannan is a complex carbohydrate isolated from the clear gel in the center of the aloe vera leaf, which consists of polymerized beta-(1,4)-linked acetylmannose. Molecular weight after purification varies from 10-1000kDa with an average of 200kDa. The precise size depends on the degree of degradation during the manufacturing process. Acemannan does not appear to be mitogenic for monocytes, macrophages, or fibroblasts and is noncytotoxic even at high concentrations.[1–3]

Many wound dressings, such as alginates and hydrocolloids, contain various forms of carbohydrates.[4]



Functions of Chicken IL-8 (cCAF) in Wound Healing

Introduction

The chicken chemotactic and angiogenic factor (cCAF) is the ortholog of human IL-8. These proteins are small inducible cytokines called chemokines. Chemokines were first identified as proteins that are critical to the process of inflammation. However, more recently, they have been shown to perform a variety of functions in biological processes, such as wound healing, atherosclerosis, and tumorigenesis. This review concentrates on cIL-8 and its role in wound healing and will also refer to other chemokines where appropriate. The author will discuss the biochemical and structural



Evaluation of Platelet-Derived Growth Factor in a Rat Model of Ischemic Skin Wound Healing

Introduction

Chronic wounds affect an estimated two million people in the United States and are a major socioeconomic burden to the patient and the healthcare system, resulting in an estimated yearly expenditure of upwards of $3 billion.[1] The basic foundation for good wound care involves eliminating exacerbating factors, such as localized pressure in pressure ulcers and diabetic foot wounds and edema in chronic venous stasis ulcers. Standard wound care procedures include wound debridement, the use of dressings to maintain a moist environment, and topical antimicrobial agents when needed t



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