Volume 20 - Issue 12 - December, 2008

MIST Therapy® System Enters New Market Within Wound Care

   Celleration, Inc., a Minneapolis-based medical device company, is expanding its patented MIST Therapy® System, an advanced wound care modality, to acute and home health care settings. The company’s primary commercialization focus for its innovative ultrasonic wound treatment device had been the product’s ability to treat chronic and hard-to-heal wounds in the outpatient and extended care markets. But because the technology has shown consistent clinical improvements and economic savings in capitated settings, physicians are interested in accessing the technology in acute



Paget’s Disease of the Breast Mimicking a Chronic Wound

Abstract: Paget’s disease of the breast is a rare malignancy of the nipple-areola complex and accounts for 1%–4% of all breast cancers. The disease is frequently associated with an underlying in-situ or invasive carcinoma in the breast tissue that extends to the nipple and areola. Paget’s disease is characterized clinically by eczema-like inflammatory skin changes and histologically by malignant cell infiltration in the dermis (Paget’s cells). Although Paget’s presents less commonly than a palpable mass or mammography abnormality, it is an important consideration in the differ



Efficiency of Therapeutic Ultrasound for Healing Venous Leg Ulcers in Surgically-treated Patients

Abstract: The aim of this study was to evaluate the efficiency of therapeutic ultrasound (US) for healing of venous leg ulcers in surgically treated patients. Study endpoints were the number of completely healed wounds and the clinical parameters predicting the outcome. Seventy patients with venous leg ulcers were included in this study, and ultimately allocated into two comparative groups. Group A consisted of 33 patients (21 women, 12 men). They were treated with the US, compression stockings, and drug therapy. Group B (control) consisted of 37 patients (22 women, 15 men). They were t



The Effects of Topical and Systemic Beta Glucan Administration on Wound Healing Impaired by Corticosteroids

Abstract: Background. Corticosteroid hormones are widely used to treat a variety of diseases. Corticosteriods have been shown to impair wound healing, which has become a serious clinical problem in wound care. The present study was designed to evaluate the efficacy of topical and systemic beta glucan administration on wound healing impaired by corticosteroids. Methods. Wistar albino rats were used for the incision and excision wound models. Percentage of wound contraction, epithelialization period, hydroxyproline level, histopathological examination, and tensile strength were evaluated.



A Review of Collagen and Collagen-based Wound Dressings

Abstract: Collagen is a key component of a healing wound. In this review, a general description of the wound healing process is provided focusing on collagen’s unique role. The mode of action (MoA) of collagen-based dressings is also addressed. Due to a number of potential stimuli (local tissue ischemia, bioburden, necrotic tissue, repeated trauma, etc.), wounds can stall in the inflammatory phase contributing to the chronicity of the wound. One key component of chronic wounds is an elevated level of matrix metalloproteinases (MMPs). At elevated levels, MMPs not only degrade nonviable



The Gift of Knowledge

Dear Readers,

   Another Thanksgiving has come and gone, and Christmas is just around the corner. As we enter the hustle and bustle of the Christmas season, rushing here and everywhere trying to get that perfect gift for everyone on our seemingly interminable lists, the question, “What is the perfect gift?” comes to mind.

   In last year’s December column I pointed out how the first Christmas gifts, though majestic for a King, had additional benefits including wound healing.1 What could I give as the perfect, one size fits all gift that all would appre



Topical Honey and Wounds

Honey on Sloughy Venous Ulcers

   Reference: Gethin, G, Cowman S. Manuka honey vs. hydrogel—a prospective, open label, multicentre, randomised controlled trial to compare desloughing efficacy and healing outcomes in venous ulcers. J Clin Nurs. 2008;Aug 23. [Epub ahead of print]

   Rationale: Expert opinion suggests honey may be effective as a wound desloughing and healing agent. Randomized controlled trials (RCTs) on chronic wounds remain to be conducted.

   Objective: Conduct a prospective RCT to explore the effects of Manuka



Industry News

Systagenix Wound Management Introduced as a New Force in Wound Care

   Systagenix Wound Management (London) is a new portfolio company created by One Equity Partners (New York, NY) that was recently launched with the intent of establishing a new global force in advanced wound care.

   Systagenix Wound Management is formerly the professional wound care business of Ethicon Inc, a Johnson & Johnson company (Somerville, NJ). The new company will focus on achieving further success, while building on its internationally renowned advanced and general woun



Product News

Smith & Nephew Launch ACTICOAT™ Flex Dressing

   The Advanced Wound Management division of Smith & Nephew (London) will launch new ACTICOAT™ Flex to expand the ACTICOAT™ family. The dressing was designed to support physicians dealing with injuries at high-risk for infection. The dressing utilizes the Silcryst® nanocrystalline silver technology and is highly conformable, which is ideal for awkward anatomical areas such as the face and hands. The dressing also improves patient comfort during wear. The new dressing will be available initially in Canada; the US an