Volume 21 - Issue 2 - February, 2009
A Comparison Between Medical Grade Honey and Table Honeys in Relation to Antimicrobial Efficacy
- Thu, 2/12/09 - 12:54pm
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Abstract: When antimicrobial agents are being evaluated prior to their introduction into clinical practice, advance publicity may interest potential users but access to that agent will normally be limited until licensed products are released and distributed. Honey is an ancient therapy that has recently been re-introduced into modern medicine. Medical grade honey (MGH) is being incorporated into sterile devices that are applied topically to wounds. Honey is universally recognized and it is readily accessible. Patients and practitioners may, therefore, consider using table honey from supermarke
Pyoderma gangrenosum and Rheumatoid Arthritis With Massive Necrotic Ulcer of the Right Foot
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Abstract: Pyoderma gangrenosum (PG) is associated with systemic disease, mostly rheumatoid arthritis (RA) and inflammatory bowel disease (IBD), in many patients (more than 50%). Lesions associated with arthritis are often ulcerative. Although these lesions typically affect the lower limbs, they can also affect the entire body.
Calciphylaxis With Recalcitrant Ulcers in the Presence of Moderate Renal Insufficiency
- Thu, 2/12/09 - 1:39pm
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Abstract: A 69-year-old woman with painful crural ulcers of 3 months’ duration presented at the authors’ outpatient clinic. Dermatological examination revealed a necrotic ulceration with eschar formation localized on the anterior left crural region and the lateral malleolus of the right ankle. According to the clinical and histopathological findings, she was diagnosed with calciphylaxis. She had moderate renal insufficiency and secondary hyperparathyroidism due to hypertension. The ulcers improved significantly after 3 months of topical wound therapy. This case of calciphylaxis with recalc
Recombinant Human Decorin Inhibits TGF-b1 Induced Contraction of Collagen Lattice by Keloid Fibroblasts
- Thu, 2/12/09 - 2:13pm
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Abstract: While wound contraction plays an important role in healing, it may lead to excessive scar formation and pathological wound contracture in extreme conditions. To date, the key regulator of wound contraction and keloid formation is transforming growth factor-beta (TGF-b1). Decorin has been reported to bind TGF-b1 and neutralize some of its activities. The present study investigated whether decorin affected TGF-b1-induced fibroblast contractile activity by using fibroblast-populated collagen lattice (FPCL), which has been generally used as an in-vitro model thought to mimic wound contra
Microarray as a New Tool To Study Hypertrophic and Keloid Scarring
- Thu, 2/12/09 - 2:27pm
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Abstract: Background. Normal wound healing results from a complex set of reactions between blood cells, skin cells, and biochemical mediators including pro- and anti-inflammatory molecules, growth factors, cytokines, hormones, and vitamins. As this cascade of reactions is ultimately regulated by the coordinated expression and silencing of numerous genes, the gene expression analysis of hypertrophic and keloid scarring (HS and KS, respectively) should provide important information and improve our understanding of HS and KS pathophysiology. Microarray is a new tool that can shed light on the com
Acute Wound Guidelines for Healing: A Must Read
- Thu, 2/12/09 - 3:52pm
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Dear Readers,
I am not a big fan of hunting, but as one who grew up in the 1950s with heroes such as Roy Rogers and the Lone Ranger, I certainly learned how to be comfortable and fairly accurate with a rifle. Last week my eldest son asked me to go hunting with him. I assure you that I am not a fan of getting up in the middle of the night to go sit in a deer stand and freeze. I told him I would go, but only in the afternoon. If you know anything about deer hunters, they must get to their deer stands 2 to 3 hours before sunset so the deer will not see them coming. As a dutif
February 2009
- Thu, 2/12/09 - 4:01pm
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Dear Editor:
This letter is in reference to Williams RL. Cadexomer Iodine: An Effective Palliative Dressing in Chronic Critical Limb Ischemia. WOUNDS. 2009;21(1):15–28.
Studies performed on a limited number of demographically similar patients without a control arm or randomization may still provide useful clinical information when the results are carefully reviewed, scrutinized, and presented in an objective fashion.
One of the conclusions drawn from this limited number of patients (n = 11) is that “cadexomer iodine is an effe
Preventing Surgical Site Infections
- Thu, 2/12/09 - 4:08pm
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Dear Readers:
What have we learned about preventing surgical site infection since 1867 when Lister first prevented surgical site suppuration and septicemia by using carbolic acid to wash wounds, soak dressings, and spray operating room air? In an experiment that laid the foundation for modern surgery,1 9 of Lister’s 11 compound fracture patients healed without amputation or mortality typical of that era. Do we know today which of Lister’s precautions was effective? Carbolic acid was soon replaced with less irritating aseptic technique. More recently, gentle
February 2009
- Thu, 2/12/09 - 4:14pm
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Oxygen Biotherapeutics Submits Request to FDA for Oxycyte® Wound Care Gel
Oxygen Biotherapeutics Inc (Costa Mesa, Calif) announced that the company recently submitted a preliminary Request For Designation (RFD) to the US Food and Drug Administration (FDA) for its first wound care product, Oxycyte® Gel. The RFD submission is part of a process that correlates with the FDA for determining which agency component will have primary jurisdiction for a drug, device, or biological product.
The gel is in a single-dose packaging delivered as an oin
February 2009
- Thu, 2/12/09 - 4:17pm
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MedEfficiency Introduces the MedE-Kast™ Ultra Total Contact Cast System
MedEfficiency (Wheat Ridge, CO) has made a gold standard an easier clinic option by introducing the MedE-Kast™ Ultra Total Contact Cast System. The new system is a simplified version of the MedE-Kast Total Contact Cast System and incorporates pre-cut splints to reduce the time required to roll a MedE-Kast. The pre-cut splints also make it easier for those new to total contact casting to learn proper application.
The time required to apply a MedE-Kast Ultra varies b
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