Controversy over efficacy of many wound treatments, particularly autologous platelet gel (APG), is common. The objective of this study was to determine if autologous platelet gel would accelerate the healing process of full-thickness cutaneous wounds in a porcine model. Autologous platelet gel with a ratio of 10:4 was created using 10 cc platelet-rich plasma and 4 cc autologous thrombin rich plasma. A punch was used to create 24 full-thickness, cutaneous round wounds on each flank of a neutered pig and were treated with APG on 1 side versus 0.9% saline (control) on the other side. The wounds were then covered with transparent vapor permeable film dressing. On Day 14 and Day 28 post-injury, all 24 wounds were photographed and digital imaging system tracings determined the area of each wound. Biopsy specimens from each wound were obtained. On Day 14, the specimens were taken from 9- and 3 o’clock positions at the edge of the round wounds, and on Day 28 the specimens were taken from 12- a

The processes behind tissue response to injury and innate immunity are integral parts of the acute wound response and the initiation of repair. In addition, inflammation is a key factor influencing both positive and negative aspects of healing in chronic wounds. Biological data on the signaling mechanisms behind these basic processes has increased dramatically over the last 10 years, yet the products and practice of wound healing have not benefited to the fullest extent from this new knowledge. An in-depth analysis of the biological mechanisms underpinning the processes that impact healing was undertaken to discover ways this information might be used to improve the treatment of chronic wounds. A synopsis of findings is presented regarding the biological mechanisms at work in injury and inflammation. It examines the early stages of wound healing from a mechanistic, biological perspective to gain insight into how this information might translate to the better use and development of woun

Porcine full-thickness wounds were treated with V.A.C.® Therapy (KCI, San Antonio, Tex) or moist wound dressing without negative pressure. V.A.C. Therapy related systemic effects included post-wound reduction in the number of peripheral blood monocytes and neutrophils during the inflammatory phase of wound healing, as well as reduced serum levels of the pro-inflammatory cytokines IFN-g and IL-6. Local effects included reduced concentrations of IL-8, TGF-b1, and TNF-a in wound fluid following V.A.C. Therapy. Collectively, these responses suggest that V.A.C. Therapy may attenuate the pro-inflammatory response following cutaneous wounding.

The authors present a case of inguinal abscess occurring after inguinal hernia repair that was treated with a silver-containing wound care product without removing the prosthesis. A 75-year-old woman presented with inguinal abscess and acute renal failure initially underwent hemodialysis and then surgical drainage. The mesh was not removed, the wound was left open for secondary healing, and daily wound care was conducted using Aquacel Ag Hydrofiber® (ConvaTec, Skillman, NJ). She was discharged 15 days after admission and her wound healed 2 months after admission.