The clinical use of honey has received increasing interest in recent years, particularly its use as a topical antibacterial dressing.Results thus far are extremely encouraging, and demonstrate that honey is effective against a broad range of microorganisms, including multiresistant strains. This in-vitro study complements the work of others and focuses on the impact that a standardized honey can have on multiresistant bacteria that are regularly found in wounds and are responsible for increased morbidity.

Staphylococcus aureus continues to be a serious health problem worldwide due to its intrinsic nature of virulence, ability to cause a wide array of infection, and its capacity to develop resistance to a number of antibiotics. The S aureus genome has continually evolved through both mutation and acquisition of exogenous genes, leading to the emergence of antibiotic-resistant strains with the ability for clonaldissemination across nations and continents. Methicillin-resistant S aureus (MRSA) is one of the most commonly identified antibioticresistant pathogens in the hospital and community settings with substantial mortality and morbidity. This review examines the accessory genome of 8 sequenced S aureus strains regarding the variety of virulence factors and mechanisms of antibiotic resistance. The remarkable nature of this organism to acquire and disseminate an array of mobile genetic elements (MBEs) through horizontal gene transfer illustrates the mechanisms for evolution and its

Acroangiodermatitis is a rare vasoproliferative disorder, usually affecting the lower limbs and is associated with congenital or acquired vascular conditions. There are two variants of acroangiodermatitis— Mali type (associated with venous hypertension) and Stewart- Bluefarb type, which is associated with arteriovenous malformation, or acquired iatrogenic arteriovenous fistula in patients with chronic renal failure. Acroangiodermatitis is clinically characterized by angiomatous papules and plaques, which mimics Kaposi’s sarcoma. The authors present a case of a 63-year-old man with acroangiodermatitis of the lower limbs and chronic venous insufficiency who was treated with elastocompressive therapy.

The effects of negative pressure wound therapy ([NPWT], V.A.C.® Therapy, KCI, San Antonio, Tex) were compared with standard dressings in 45 patients with diabetic foot ulcers who were admitted to the Department of Plastic and Reconstructive Surgery, Medical Park Hospital, Bursa, Turkey. Twenty-four patients were randomly divided into 2 groups—NPWT group and control group. Initially, the mean surface area of wounds in the NPWT group was 109 cm2, the control group 94.8 cm2. The mean duration of open wound care was 11.25 days in the NPWT group and 15.75 days in the control group (P =0.05). After wound management, mean surface area of the diabetic wounds was 88.6 cm2 in the NPWT group, and 85.3 cm2 in the control group (P < 0.05). The use of NPWT may be an effective initial wound therapy to achieve faster wound bed granulation in diabetic foot ulcers. Further studies are needed to clarify the effects and indications and to modify the technique of this alternative treatment for use on