Celleration, Inc., a Minneapolis-based medical device company, is expanding its patented MIST Therapy® System, an advanced wound care modality, to acute and home health care settings. The company’s primary commercialization focus for its innovative ultrasonic wound treatment device had been the product’s ability to treat chronic and hard-to-heal wounds in the outpatient and extended care markets.

Abstract: The aim of this study was to evaluate the efficiency of therapeutic ultrasound (US) for healing of venous leg ulcers in surgically treated patients. Study endpoints were the number of completely healed wounds and the clinical parameters predicting the outcome. Seventy patients with venous leg ulcers were included in this study, and ultimately allocated into two comparative groups. Group A consisted of 33 patients (21 women, 12 men). They were treated with the US, compression stockings, and drug therapy. Group B (control) consisted of 37 patients (22 women, 15 men).

Abstract: Collagen is a key component of a healing wound. In this review, a general description of the wound healing process is provided focusing on collagen’s unique role. The mode of action (MoA) of collagen-based dressings is also addressed. Due to a number of potential stimuli (local tissue ischemia, bioburden, necrotic tissue, repeated trauma, etc.), wounds can stall in the inflammatory phase contributing to the chronicity of the wound. One key component of chronic wounds is an elevated level of matrix metalloproteinases (MMPs).

Honey on Sloughy Venous Ulcers

   Reference: Gethin, G, Cowman S. Manuka honey vs. hydrogel—a prospective, open label, multicentre, randomised controlled trial to compare desloughing efficacy and healing outcomes in venous ulcers. J Clin Nurs. 2008;Aug 23. [Epub ahead of print]

   Rationale: Expert opinion suggests honey may be effective as a wound desloughing and healing agent. Randomized controlled trials (RCTs) on chronic wounds remain to be conducted.

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