Abstract: Negative pressure wound therapy (NPWT) has consistently shown significant clinical benefits in wound healing, but the mechanisms are not fully elucidated. While a reduction in bacterial burden is one possible contributor, studies have shown mixed results in this regard. The present study used a porcine infected wound model to test the effect of NPWT on bacterial burden. Methods. Infected wounds (Pseudomonas aeruginosa, coagulase negative Staphylococcus, and Bacteroides fragilis) in a porcine model were treated with V.A.C.® therapy with the standard GranuFoam™ dressing, V.A.C.

Abstract: Pressure ulcers that develop from deep tissue are known as deep tissue injuries (DTI). Although several mechanisms, including ischemic hypoxia, are attributed to pressure ulcer formation, the mechanisms involved in DTI formation are still unclear. Previous studies have suggested that hypoxia is involved in DTI in vitro, but it has yet to be determined whether hypoxia is also involved in DTI in vivo. Therefore, this study aimed to investigate whether hypoxia is involved in DTI using a newly established DTI model.

     Worldwide disasters have not been in short supply in the past few years, but none has grabbed our attention more than the recent earthquake in Haiti. As you know from the news reports, the entire country has been devastated. Many people were killed in the initial event and many others have perished in the aftermath. Lack of food, water, and other basic needs is pervasive.

Healthpoint Expands Regenerative Medicine Portfolio with New Acquisition

Abstract: A 36-year-old man presented with pyoderma gangrenosum associated with cocaine abuse. The patient presented to our department with a 2-week history of ulceration on the left forearm at a skin graft donor site following surgical intervention to repair a perforation of the nasal septum and palate due to cocaine abuse of at least 10 years’ duration—an estimated dosage of up to 2 g/day. Standard medications and additional substance abuse were not described in the patient’s medical history.

Address correspondence to:
Joachim Dissemond, MD
Department of Dermatology