Current Issue

Effect of Ascorbic Acid on Incisional Wound Healing in Streptozotocin-Induced Diabetic Rats

admin — Wed, 17 Feb 2010 10:13:56 -0500

Abstract: Background. Abdominal wall repair after celiotomy is important because insufficient incisional wound strength results in wound failures such as fascial dehiscence and herniation. Ascorbic acid has been shown to play an important role in wound healing. The purpose of this study was to investigate whether ascorbic acid improves incisional wound healing in a diabetic rat. Methods. Male Wistar-Albino streptozosin-induced diabetic rats (n = 20) were divided into two groups: control group (CG; n = 10), and daily 200 mg/kg ascorbic acid (study group, [SG], n = 10) given orally.

Bacterial Burden and Wound Outcomes as Influenced by Negative Pressure Wound Therapy

admin — Wed, 17 Feb 2010 10:40:24 -0500

Abstract: Negative pressure wound therapy (NPWT) has consistently shown significant clinical benefits in wound healing, but the mechanisms are not fully elucidated. While a reduction in bacterial burden is one possible contributor, studies have shown mixed results in this regard. The present study used a porcine infected wound model to test the effect of NPWT on bacterial burden. Methods. Infected wounds (Pseudomonas aeruginosa, coagulase negative Staphylococcus, and Bacteroides fragilis) in a porcine model were treated with V.A.C.® therapy with the standard GranuFoam™ dressing, V.A.C.

Validity of Diagnosis of Superficial Infection of Laparotomy Wounds Using Digital Photography

admin — Wed, 17 Feb 2010 10:57:27 -0500

Abstract: Background. The use of digital photography to assess and document the wound healing process has become increasingly popular. One of the most common complications of wound healing is infection, but the validity of digital photography for the diagnosis of wound infection is unknown. We intended to measure the degree of inter and intra-observer agreement on the diagnosis of superficial wound infection using digital photography. Methods. In a prospective, observational clinical study, abdominal wounds were photographed daily and signs of infection were documented in a standard manner.

Hypoxia is Involved in Deep Tissue Injury Formation in a Rat Model

admin — Wed, 17 Feb 2010 11:22:12 -0500

Abstract: Pressure ulcers that develop from deep tissue are known as deep tissue injuries (DTI). Although several mechanisms, including ischemic hypoxia, are attributed to pressure ulcer formation, the mechanisms involved in DTI formation are still unclear. Previous studies have suggested that hypoxia is involved in DTI in vitro, but it has yet to be determined whether hypoxia is also involved in DTI in vivo. Therefore, this study aimed to investigate whether hypoxia is involved in DTI using a newly established DTI model.

Geoff Mackay, President and CEO Organogenesis, Inc. ‘Living Technology’

admin — Wed, 17 Feb 2010 13:13:16 -0500

For Geoff Mackay, President and CEO of Organogenesis (Canton, Mass), the pharmaceutical business feels more and more like a second home. He has become increasingly familiar with the industry through various leadership positions during his 11 years with Novartis AG (Basel, Switzerland) and other international companies and he is proud of his role in fulfilling the promise of regenerative medicine.

When Disaster Strikes

admin — Wed, 17 Feb 2010 13:48:32 -0500

Worldwide disasters have not been in short supply in the past few years, but none has grabbed our attention more than the recent earthquake in Haiti. As you know from the news reports, the entire country has been devastated. Many people were killed in the initial event and many others have perished in the aftermath. Lack of food, water, and other basic needs is pervasive.

Moist Wound Healing With Limited Resources

admin — Wed, 17 Feb 2010 13:56:31 -0500

Dear Readers:

Industry News February 2010

admin — Wed, 17 Feb 2010 14:43:58 -0500

Healthpoint Expands Regenerative Medicine Portfolio with New Acquisition

Product New February 2010

admin — Wed, 17 Feb 2010 14:46:03 -0500

Synovis Life Technologies to Distribute MicroClip™ Globally

Pyoderma gangrenosum Associated With Cocaine Abuse

admin — Wed, 17 Feb 2010 16:02:40 -0500

Abstract: A 36-year-old man presented with pyoderma gangrenosum associated with cocaine abuse. The patient presented to our department with a 2-week history of ulceration on the left forearm at a skin graft donor site following surgical intervention to repair a perforation of the nasal septum and palate due to cocaine abuse of at least 10 years’ duration—an estimated dosage of up to 2 g/day. Standard medications and additional substance abuse were not described in the patient’s medical history.

Address correspondence to:
Joachim Dissemond, MD
Department of Dermatology