From The Journal

Characteristics of Surgical Site Infection Following Colorectal Surgery in a Tertiary Center: Extended-spectrum β-Lactamase-producing Bacteria Culprits in Disease

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Abstract

Introduction. Surgical site infection (SSI) is a well-known complication of colorectal surgery associated with increased morbidity and hospital stay. Antimicrobial prophylaxis can reduce the risk of SSI by as much as 75%. Extended-spectrum β-lactamase (ESBL)-producing pathogens make the successful use of such prophylaxis a challenge and are a real threat to patient care following colorectal surgery....

Understanding Diabetic Induction of Cellular Senescence: A Concise Review

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Abstract

Cellular senescence is a fundamental aging mechanism that has been implicated in many age-related diseases and is a significant cause of tissue dysfunction. Cellular senescence also underlies many age-related chronic inflammatory diseases, including the components of metabolic syndrome (hypertension, obesity, and atherosclerosis); by translation, diabetes itself is a consequence of this cellular derangement. Senescent cells may play a role in type 2 diabetes pathogenesis through direct impact on pancreatic beta-cell function, senescence-associated secretory phenotype-mediated tissue damage, and involvement in adipose tissue dysfunction. Therefore, the metabolic dysfunctions seen in diabetes, such as hyperglycemia, alterations in lipid metabolism, and growth hormone axis deviations, can promote senescent cell formation. Thus, senescent cells might be part of a pathogenic loop in diabetes as both a cause and consequence of metabolic changes and tissue damage....

Use of Viable Cryopreserved Umbilical Tissue for Soft Tissue Defects in Patients With Gas Gangrene: A Case Series

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Abstract

Introduction. Gas gangrene is a rapidly progressive bacterial infection leading to necrosis that usually develops as a result of trauma or postoperative complications. This condition requires early diagnosis with immediate surgical intervention. With a poor prognosis, a high incidence of amputation, and comorbidities such as diabetes and peripheral vascular disease, patients with gas gangrene are put at further risk for surgical complications....

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A Total Offloading Foot Brace for Treatment of Diabetic Foot Ulcers: Results From a Halted Randomized Controlled Trial

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Abstract

Introduction. Foot offloading is the mainstay treatment for plantar diabetic foot ulcers (DFUs). Objective. This multicenter, single-blinded, randomized controlled trial evaluates the efficacy of a total offloading foot brace for healing plantar DFUs....

Comparison of DNA Damage and Apoptosis Induced By Silver Nanoparticle-containing Dressing Materials During Wound Healing

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Abstract

Introduction. Silver nanoparticle (AgNP)-containing dressings are used worldwide for the treatment of wounds; however, many studies have indicated that AgNPs are toxic to humans and cause cell death, primarily via apoptosis....

Clinical Applications and Validation of an Innovative Wound Score

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Abstract

Objective. This study demonstrates the applicability of an innovative wound score that summates 5 assessments using 2-point (best) to 0-point (worst) grades based on specific findings to generate a 0- to 10-point wound score for categorizing diabetic foot ulcers as well as validates its effectiveness....

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Introduction. Amelanotic melanoma of the foot is a diagnostic challenge for physicians as it often appears as a benign lesion. In order to make the correct diagnosis at early stages, it is recommended to perform a biopsy of worsening lesions that are refractory to standard treatments, particularly nonhealing wounds.

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