Introduction. While the determination of optimal moisture needed for the wound healing process is an enigma, the complications of excessive moisture are readily recognized by clinicians in the field of wound care. Excess moisture can cause maceration of the periwound and degradation of the surrounding healthy skin due to the proteolytic enzymes found in chronic wound exudate. Maceration can impede healing and can potentially cause further deterioration of the wound bed. To date, a number of advanced wound care dressings have been designed to provide a moist wound environment, but little research has been done to understand the ability of the dressing to protect the periwound and surrounding healthy skin from excess exudate. Materials and Methods. An in vitro method was developed to examine the amount of exudate to which the periwound and healthy skin are exposed using a simulated wound model. After the 48-hour test, a noticeable difference was observed in the amount of fluid present on the simulated periwound between each of 4 dressings tested: an Active Fluid Management silver dressing (TRITEC Silver Milliken Healthcare Products, LLC, Spartanburg, SC), a hydroconductive dressing (Drawtex, Steadmed Medical, Fort Worth, TX), a nanocrystalline silver dressing (Acticoat Antimicrobial Silver dressing, Smith & Nephew, Memphis, TN), and a hydrofiber dressing (Aquacel, ConvaTec, Skillman, NJ). Gauze (Curity All Purpose Sponges, Covidien, Mansfield, MA) was also evaluated as a negative control. This fluid was quantified as a weight percent of exudate absorbed by the simulated periwound based on the initial weight of the simulated periwound. Results. After the 48-hour test, gauze exposed the periwound to the greatest amount of fluid (588% ± 41.89), followed by the hydrofiber silver dressing (205% ± 30.68), nanocrystalline silver dressing (179% ± 30.68), hydroconductive dressing (167% ± 13.51), and active fluid management dressing (31% ±4.09). Conclusion. The active fluid management dressings exposed the simulated periwound to the least amount of moisture, indicating that Active Fluid Management dressings provide greater protection of the periwound compared to the other dressings.