A remote therapy monitoring (RTM) system has been developed for use with a negative pressure wound therapy (NPWT) unit for patients in the home care setting. In conjunction with RTM, a network of trained professionals call patients when their NPWT usage is low and provide education to assist with therapy adherence. Objective. The objective of this evaluation is to examine the relationship between the RTM system and patient adherence. Materials and Methods. One hundred ninety-eight home care patients receiving NPWT with RTM between December 2016 and April 2017 were included. Results. A total of 979 calls were made, with an average of 4.9 calls per patient. Among 198 patients, 195 received a welcome call, 157 received a call due to low adherence, and 35 had an escalation call made to their treating nurse. Of the 157 patients who required at least 1 call due to low adherence, 153 were successfully contacted at least once. The day following the patient call, adherence increased 73% of the time by an average of 8.5 hours. Conclusions. This evaluation suggests there is an ability to influence patient adherence through active engagement, potentially improving outcomes and reducing wound costs.