Objective. The aim of this meta-analysis was to evaluate the efficacy of a hydrocolloid dressing in the treatment of pressure ulcers compared with a traditional gauze dressing. Methods. Randomized controlled trials were identified by searching PubMed and Web of Science. Outcomes were complete wound healing rate and reduction in wound volume or surface area. Results. Seven studies with 302 patients (337 pressure ulcers) were included. Hydrocolloid dressings were associated with a statistically significant improvement of complete wound healing rate compared with gauze dressings (Odds ratio = 3.642, 95% Confidence Interval 1.104 to 12.012, z = 2.12, P = 0.034). Possible publication bias exists in this meta-analysis. Three studies also confirmed the hydrocolloid dressing was associated with a statistically significant reduction in wound volume compared with the gauze dressing. Conclusion. The existent evidence shows that a hydrocolloid dressing is more effective than a gauze dressing for pressure ulcer treatment. Accordingly, the authors suggest that in the treatment of pressure ulcers, traditional gauze dressings should be abandoned.