Introduction. Negative pressure wound therapy (NPWT) dressings are beneficial tools for promoting granulation tissue and wound healing. An NPWT dressing with instillation and dwell time (NPWTi-d) is becoming more frequently used to provide daily, effective wound cleansing between surgical debridement procedures. Either saline or other wound solutions, such has hypochlorous acid wound solution, can be instilled in small volume aliquots to irrigate the wound periodically. Objective. This case series describes the effective use of NPWTi-d in conjunction with hypochlorous acid (HOCl) solution in 10 patients with necrotizing soft tissue infections (NSTIs). Materials and Methods. The hospital registry of patients between July 2018 and June 2020 was queried to identify patients older than were 18 years or older, whose wounds were managed intermittently with NPWTi-d using HOCl wound solution, regardless of wound etiology. Wound and patient demographics were reported. Results. A total of 10 cases in which NPWTi-d was utilized in conjunction with HOCl were identified. Of the 10 patients, 6 were admitted for NSTIs, 2 were admitted for sacral decubitus ulcers, and 2 were admitted for burn injuries. The patients’ wounds ranged from 30 cm2 to 1000 cm2, and 80% of patients ultimately underwent skin grafting for wound closure. Conclusions. This case series highlights the spectrum of wounds that can be managed with NPWTi-d dressings to yield a clean wound environment to promote healing and preparation for wound closure.