Objective. This retrospective study of 510 patients receiving negative pressure wound therapy (NPWT) in a home care setting examines the relationship between remote therapy monitoring (RTM) and patient adherence, as well as determines the impact of patient adherence on wound progression. Materials and Methods. Adherence to treatment was continuously monitored via RTM, and patients with therapy usage < 16 hours in 1 day received an adherence call. Repeated failures to reach a noncompliant patient led to an escalation call to the caregiver to discuss treatment. Wound volume and surface area were collected to determine the rate of wound size reduction. Results. A total of 3261 calls were made with an average of 6.4 calls per patient. Among the 510 patients, 98% received a welcome call, 87% received at least 1 call due to low adherence, and 30% received an escalation call. The day following an adherence call, 73.5% of patients increased therapy use. As adherence to NPWT increased (< 60% to 90%–100% therapy use), there was an increase in the daily reduction rate in wound volume (1.42% to 2.23%) and surface area (0.86% to 1.45%). Conclusions. The data suggest RTM can be used to influence patient behavior, and there may be a potential relationship between patient behavior and wound healing outcomes. Additional studies are needed to elucidate the relationship between RTM and wound outcomes.