Although many topical agents (including biologic products) are available for the treatment of psoriasis, clinicians may still be concerned about the side-effect profile, efficacy, and expected result of each of these therapies. Case Report. Herein, the authors suggest an alternative, cost-effective option that may help in the management of psoriatic plaques. The authors have investigated the efficacy of topical natural honey versus fluticasone propionate in a 28-year-old man with plaque psoriasis diagnosed previously by biopsy at the main dermatology clinic at Hamad General Hospital (Doha, Qatar). The patient was treated with topical preparation of coal tar and moderate topical corticosteroids intermittently over a 3-year time period prior to presentation; however, he was unsatisfied with the outcome. The purpose of this case report is to offer a primary care-based approach utilizing natural honey as a safe and effective alternative treatment for adult patients with chronic plaque psoriasis. To the best of the authors’ knowledge, this is the first report in the medical literature proposing the use of natural honey in the treatment of psoriasis. Conclusions. Although this case report demonstrates a successful outcome of topical application of honey in the management of mild psoriasis, randomized controlled trials will be needed to verify these results.