Clinical Achievement of Wound Closure and Tissue Quality With a Novel Microvascular Tissue Graft in Five PatientsCharles Zelen, DPM; Lisa Gould, MD; and William W. Li, MD
BACKGROUND: The quality of healed tissue is frequently overlooked in clinical trials that primarily focus on rate and incidence of wound closure. Microvascular tissue serves as the foundation for granulation and remodeling during healing. Optimal repair of microvascular structure and function is essential for future healing capacity and to minimize tissue breakdown in a newly epithelialized wound. This is especially true when the tissue microenvironment is intrinsically compromised by advanced age, diabetes, small vessel disease, or radiation. A novel processed microvascular tissue graft (PMVT) contains multiple biological factors and structures capable of stimulating tissue repair, regeneration, and angiogenesis.
MATERIALS AND METHODS: Five patients with nonhealing diabetic foot ulcers (DFUs) ranging from 1.1 cm2 to 11.2 cm2 (mean, 4.6 cm2 ± 4.1 cm2), recalcitrant to standard care and, in 2 cases, advanced therapies, were treated weekly with topical PMVT and standard of care. Wound closure was measured using infrared imaging. Fluorescence microangiography was used to quantify wound microcirculation and to assess the perfusion quality in healed tissues. Changes in ingress and egress rates were tracked at each visit to evaluate inflammation and microvascular integrity.
RESULTS: All wounds healed within 19 weeks (average, 9 weeks). Assessment of healed wounds at the time of closure indicated PMVT treatment significantly improved perfusion within the newly healed wound site and throughout the immediate surrounding tissues. No wound recurrence or tissue deterioration has been observed in more than 9 months of follow-up.
CONCLUSIONS: These results support the use of PMVT as a potent new advanced wound therapy to reconstruct local microcirculation and close nonhealing wounds, resulting in robust and well-vascularized tissue. Additional clinical studies are warranted.
Zelen C, Gould L, Li WW. Clinical achievement of wound closure and tissue quality with a novel microvascular tissue graft in five patients. Poster presented at: Symposium on Advanced Wound Care Fall; November 2-4, 2018; Las Vegas, NV.
Product: mVASC, MicroVascular Tissues, Inc (San Diego, CA)
This abstract was not subject to the WOUNDS peer-review process.